The Regional Steering Committee was established based on the following guiding principles:

1.Ensuring that grant implementation is focused, fast and flexible
2.Ensuring access to high quality data
3.Enabling real partnership:  thinking big and thinking big together
4.Creating political leverage and joint funding platforms through linking with regional Asia Pacific organizations
5.Complementing the role of national Country Coordinating Mechanisms (CCMs)
6.Ensuring a transparent process for engagement of the right implementing partners

The RSC collaborates with the Principal Recipient, national CCMs, Global Fund, LFA and technical partners to provide strategic direction and oversight to the RAI grant.

The RSC works closely with the World Health Organization through the support of the Emergency Response to Artemisinin Resistance Hub (ERAR), based in Phnom Penh, Cambodia.